The Effect of Isoflavone in Cowpea (Vigna unguiculata) Powder Supplement on Post-Menopausal Vaginal Maturation Index at Malang, Indonesia

Authors

  • Tatik Sujiati Department of Obstetrics and Gynecology, Faculty of Medicine, Brawijaya University/Saiful Anwar General Hospital, Malang, East Java, Indonesia
  • Budi Siswanto Department of Obstetrics and Gynecology, Faculty of Medicine, Brawijaya University/Saiful Anwar General Hospital, Malang, East Java, Indonesia
  • A Hidayat Department of Obstetrics and Gynecology, Faculty of Medicine, Brawijaya University/Saiful Anwar General Hospital, Malang, East Java, Indonesia
  • Ayu Rizky Widowati Department of Obstetrics and Gynecology, Faculty of Medicine, Brawijaya University/Saiful Anwar General Hospital, Malang, East Java, Indonesia

DOI:

https://doi.org/10.55561/ajhr.v1i1.10

Keywords:

Isoflavone, Cowpea, Maturation vaginal index

Abstract

Background: Only a few published studies have directly demonstrated the effects of local soy isoflavone on the post-menopausal vaginal maturation index. This study focused on the effect of 24 weeks of local soy isoflavone (67,5 mg) consumption to improve the post-menopausal vaginal maturation index.

Material and Methods: 50 post-menopausal women were randomly assigned to a double-blind clinical trial to receive cowpea (Vigna unguiculata) powder treatment (n=25) and placebo (n=23). Vaginal cytology (maturation index, maturation value) was evaluated at pre and post-treatment in Anatomy Pathology Laboratories. Collected data were analyzed by using the analysis of covariant (ANOVA) method.

Result: There is no difference in maturation vaginal index between the treatment and the placebo group. The treatment was not significantly improved the vaginal maturation index (p<0,05). The concomitant variable, age, post-menopausal interval, BMI, marital status, and initial cell condition have no significant effect on the maturation vagina index.

Conclusion: Cowpea powder supplement with 67,5 mg isoflavone cannot improve the vaginal maturation index on post-menopausal patients.

Downloads

Published

2022-03-05